Search on: COMPLEMENT C8 
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Descriptor English:   Complement C8 
Descriptor Spanish:   complemento C8 
Descriptor Portuguese:   Complemento C8 
Synonyms English:   C8 Complement
C8, Complement
Complement 8
Complement Component 8
Complement Component C8 alpha
Complement Component C8 alpha Chain
Complement Component C8 beta
Complement Component C8 beta Chain
Complement Component C8 gamma
Complement Component C8 gamma Chain
Complement, C8
Component 8, Complement  
Tree Number:   D12.776.124.486.274.750
Definition English:   A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9. 
Pharmacological Action:   Immunologic Factors
 
History Note English:   2006 (1975) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22139 
Unique Identifier:   D003185 

Occurrence in VHL: 		 

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DeCS